Detection of Insulin Resistance in Normoglycemic First-Degree Relatives of Type 2 Diabetics: Harbinger of Diabetes Mellitus


  • Kamalakar Bhagwat Mane Department of Biochemistry, Dr. V. M. Government Medical College, Solapur, Maharashtra, India.
  • Shilpa Balaji Asegaonkar Department of Biochemistry, Government Medical College, Aurangabad, Maharashtra, India.
  • Swati Digambar Sawant Department of Biochemistry, Dr. V. M. Government Medical College, Solapur, Maharashtra, India.


Normoglycemic, Insulin, HOMA-IR, hs-CRP, T2DM, First-degree relatives


Background: Diabetes has a strong familial aggregation in Asian Indians, with a high prevalence among the first-degree relatives and vertical transmission through two or more generations. First-degree relatives of T2DM are at significant risk for developing T2DM.

Aim: Evaluation of insulin resistance in normoglycemic first-degree relatives of type 2 diabetic patients.

Methods: A total of 200 subjects were divided into two groups. Group A comprises non-diabetic first-degree relatives of T2DM patients between the age group of 20 to 50 years. Group B comprises healthy controls without a family history of T2DM. Subjects were analyzed for fasting plasma glucose level, fasting serum Insulin and fasting serum hs-CRP.

Result: The mean value of blood sugar level did not show a significant difference between cases and controls (92.02 ± 9.23 Vs. 91.77 ± 7.99; p > 0.05). The mean values of insulin (12.52 ± 3.65 vs. 5.08 ± 1.42), HOMA-IR (2.86 ± 0.95 vs. 1.15 ± 0.34) and hs-CRP (2.4 ± 1.98 vs. 1.0 ± 0.38) (all p < 0.001) increased in cases as compared to controls. Fasting serum insulin shows a positive correlation with HOMA-IR and hs-CRP (p < 0.001). HOMA-IR strongly correlates with hs-CRP and shows a positive correlation (p < 0.05). Insulin and HOMA-IR shows strong positive correlation with each other (r = 0.94; p < 0.001).

Conclusion: Normoglycemic first-degree relatives of type 2 diabetic patients were insulin resistant compared to individuals without family history of type 2 diabetes.


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How to Cite

Mane, K. B., Asegaonkar, S. B., & Sawant, S. D. (2022). Detection of Insulin Resistance in Normoglycemic First-Degree Relatives of Type 2 Diabetics: Harbinger of Diabetes Mellitus. Advances in BioScience, 13(1), 1–7. Retrieved from