Antidiabetic Effects of Momordica charantia (Karela) in Male long Evans Rat

  • Nurul Karim Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Md. Alamgir Z. Chowdhury Agrochemical and Environmental Research Division, Institute of Food and Radiation Biology, Atomic Energy Research Establishment, Ganakbari, Savar, Dhaka-1000, Bangladesh.
  • M. Ibrahim Hossain Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Md. Sabir Hossain Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Sohel Ahmed Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh.
  • Tanzila Afrin Department of Pharmacy, East-West University, Aftab Nagar, Dhaka-1219, Bangladesh.
Keywords: Momordica charantia, Antidiabetic effect, Streptozotocin, Hexose monophosphate shunt

Abstract

The hypoglycemic effect of Momordica charantia (Karela) has been reported from many laboratories. To our knowledge, the underlying biochemical mechanism of action of this important clinical effect has not been reported. During the course of investigation of this aspect of the herbal fruit, it was reported from our laboratory that ethanolic extract of Momordica charantia suppressed gluconeogenesis in normal and streptozotocin (STZ) induced diabetic rats by depressing the hepatic gluconeogenic enzymes fructose-1,6-bisphosphatase and glucose-6-phosphatase. The herbal extract had also enhanced the activity of glucose-6-phosphate dehydrogenase, the rate-limiting enzyme of hexose monophosphate shunt (a pathway for the oxidation of glucose).

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Published
2012-07-01
How to Cite
Karim, N., Chowdhury, M., Hossain, M., Hossain, M., Ahmed, S., & Afrin, T. (2012). Antidiabetic Effects of Momordica charantia (Karela) in Male long Evans Rat. Journal of Advanced Laboratory Research in Biology, 3(3), 175-180. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/122
Section
Articles
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