Relation of Particle size with Toxicity of Calcite Particles
Keywords:Nanoparticles, Clay particles, Chemical properties, Particle size
The importance of certain types of nanomaterials and mineral nanoparticles, namely clays and the smallest mineral colloids, has been known for a long time. Mineral nanoparticles also behave differently than larger micro and macroscopic crystals of the same mineral. The variations in chemical properties are most likely due to differences in surface and near surface atomic structure, as well as crystal shape and surface topography as a function of size in this smallest of size regimes. Although most of the nanotoxicological studies were performed using unrealistic exposure conditions. Knowledge about potential human and environmental exposure combined with dose response, toxicity information will be necessary to determine real or perceived risks of nanomaterials following inhalation, oral or dermal routes of exposure. Because the respiratory tract is the major portal of entry for airborne nanoparticles, this exposure route can be used as an example to discuss some key concepts of nanotoxicology, including the significance of dose, dose rate, dose metric and biokinetics.
. Donaldson, K., Li, X.Y., MacNee, W. (1998). Ultrafine (nanometre) particle mediated lung injury. Journal of Aerosol Science, 29: 553–560.
. Ellenhorn, M.J. and D.G. Barceloux (1998). Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc., 53-171.
. Gilmour, P., Brown, D.M., Beswick, P.H., Benton, E., MacNee, W., Donaldson, K. (1997). Surface free radical activity of PM10 and ultrafine titanium dioxide: A unifying factor in their toxicity? The Annals of Occupational Hygiene, 41 (Suppl. 1): 32-38.
. Kampalath, B.N, McMahon, J.T., Cohen, A., Tomashefski, J.F. and Kleinerman, J. (1998). Obliterative central bronchitis due to mineral dust in patients with pneumoconiosis. Archives Pathol. Lab. Med., 122(1): 56–62.
. Lin, W., Huang, Y.W., Zhou, X.D., Ma, Y., (2006). In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicology and Applied Pharmacology, 217: 252– 259.
. Mates, J.M., Pérez-Gómez, C., Núñez de Castro, I. (1999). Antioxidant enzymes and human diseases. Clin Biochem., 32(8):595-603.
. Nel, A., Xia, T., Madler, L., Li, N. (2006). Toxic potential of materials at the nanolevel. Science, 311: 622–627.
. Oberdorster, G. (2000). Toxicology of ultrafine particles: In vivo studies. Phil. Trans. R. Soc. Lond. A, 358: 2719-2740.
. Oberdorster, G. (1996). Significance of particle parameters in the evaluation of exposure–dose–response relationships of inhaled particles. Inhalation Toxicology, 8: 73–89.
. Oberdorster, G., Ferin, J., Gelein, R., Soderholm, S.C., Finkelstein, J. (1992). Role of alveolar macrophage in lung injury: studies with ultrafine particles. Environmental Health Perspective, 97: 193–199.
. Oberdorster, G., Gelein, R.M., Ferin, J., Weiss, B. (1995). Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhalation Toxicology, 7: 111–124.
. Oberdorster, G., Oberdorster, E., Oberdorster, J. (2005). Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect., 113(7):823-39.
. Osim, E.E. and Esin, R.A. (1996). Lung function studies in some Nigerian bank workers. Central Afr. J. Med., 42 (2): 43–46.
. Wang, X., Yano, E., Nonaka, K., Wang M. and Wang, Z. (1997). Respiratory impairment due to dust exposure: A comparative study among workers exposed to silica, asbestos and coalmine dust. Am. J. Ind. Med., 31 (5): 495–502.
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