Comparative In silico Analysis of Hypertrophic Cardiomyopathy Heart in Human and Normal Chicken Heart

  • G. Thiyagarajan Department of Biotechnology, Central Leather Research Institute, Adyar, Chennai-600 020, Tamil Nadu, India.
  • Suganthi Karunanithi Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi-627 412, Tirunelveli, Tamil Nadu, India.
  • Lakshmanan Venkatachalapathy Department of Cardio-Thoracic Surgery, MMC, Chennai-632003, Tamil Nadu, India.
  • Yamini Sudhalakshmi Department of Basic Health Sciences, Asmara College of Health Sciences, Asmara, Eritrea, Africa.
  • A. G. Murugesan Sri Paramakalyani Centre for Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi-627 412, Tirunelveli, Tamil Nadu, India.
Keywords: Hypertrophic Cardiomyopathy, Beta-myosin Heavy Chain, CLUSTALW, Phylogenetic tree

Abstract

Hypertrophic Cardiomyopathy (HCM) is an incurable disease, which causes excessive thickening of the myocardium. HCM is caused by abnormalities in genes which code for the proteins responsible for contraction of the heart. The anatomical resemblances between the Chicken heart and HCM heart are thickening of the muscle of the left ventricle, localized ring- like thickening of muscle under the aortic valve, and poorly formed anterior ventricular groove, and left ventricle projecting beyond the right ventricle. The mutations for the genes are retrieved from the databases: Human Genome Mutation Database, Familial Hypertrophic Mutation Database and Cardiogenomics databases. Since the Beta-myosin Heavy Chain (MYH7) is more predominant in causing HCM, that gene alone is taken and compared with normal chicken heart myh7 gene. The amino acids were aligned by CLUSTAL W and they were found to have sequence homology of 85%. The phylogenetic tree was constructed by using PHYLIP to study evolutionary linkage. According to the results, it can be presumed that the chicken normal gene, during the evolutionary process have undergone many modifications and evolved as a complicated and advanced human heart.

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References

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Published
2010-07-01
How to Cite
Thiyagarajan, G., Karunanithi, S., Venkatachalapathy, L., Sudhalakshmi, Y., & Murugesan, A. (2010). Comparative In silico Analysis of Hypertrophic Cardiomyopathy Heart in Human and Normal Chicken Heart. Journal of Advanced Laboratory Research in Biology, 1(1), 60-63. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/18
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Articles
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