Anatomical Changes in the Skin of Rattus norvegicus after Artificial UV Exposure

Authors

  • P. N. Saxena Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India.
  • Nausheen Saba Khanam Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India.
  • Nishi Saxena Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002, U.P., India.

Keywords:

UVB exposure, Albino rats, Hyperplasia, Epidermal and dermal cell, Morphological and Histological changes

Abstract

Acute and subacute artificial UV exposure to albino rats exhibit morphological and histo-anatomical changes in the skin of albino rat. The anatomical changes include hyperplasia, hyperkeratosis, hypergranulosis and acanthosis beside numerical changes in keratinocytes, Langerhans, melanocytes and fibroblast seen after acute and subacute artificial UVB exposure.

Downloads

Download data is not yet available.

References

Baba, H., Yoshida, M., Yokota, T., Uchiwa, H. & Watanabe, S. (2005). Human epidermal basal cell responses to ultraviolet-B differ according to their location in the undulating epidermis. J. Dermatol. Sci., 38(1): 41–46. https://doi.org/10.1016/j.jdermsci.2004.12.020.

Baba, T., Hanada, K. & Hashimoto, I. (1996). The study of ultraviolet B-induced apoptosis in cultured mouse keratinocytes and in mouse skin. J. Dermatol. Sci., 12(1): 18–23. https://doi.org/10.1016/0923-1811(95)00452-1.

Bacci, S., Romagnoli, P. & Streilein, J.W. (1998). Reduction in number and morphologic alterations of Langerhans cells after UVB radiation in vivo are accompanied by an influx of monocytoid cells into the epidermis. J. Invest. Dermatol., 111(6): 1134–1139. https://doi.org/10.1046/j.1523-1747.1998.00406.x.

Bayerl, C., Taake, S., Moll, I. & Jung, E.G. (1995). Characterization of sunburn cells after exposure to ultraviolet light. Photodermatol. Photoimmunol. Photomed., 11(4): 149–154. https://doi.org/10.1111/j.1600-0781.1995.tb00157.x.

Deliconstantinos, G., Villiotou, V. & Stravrides, J.C. (1995). Release by ultraviolet B (u.v.B) radiation of nitric oxide (NO) from human keratinocytes: a potential role for nitric oxide in erythema production. Br. J. Pharmacol., 114(6): 1257–1265. https://doi.org/10.1111/j.1476-5381.1995.tb13341.x.

El-Abaseri, T.B., Putta, S. & Hansen, L.A. (2006). Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis, 27(2): 225–231. https://doi.org/10.1093/carcin/bgi220.

Gambichler, T., Boms, S., Stücker, M., Moussa, G., Kreuter, A., Sand, M., Sand, D., Altmeyer, P. & Hoffmann, K. (2005). Acute skin alterations following ultraviolet radiation investigated by optical coherence tomography and histology. Arch. Dermatol. Res., 297(5): 218–225. https://doi.org/10.1007/s00403-005-0604-6.

Gambichler, T., Künzlberger, B., Paech, V., Kreuter, A., Boms, S., Bader, A., Moussa, G., Sand, M., Altmeyer, P. & Hoffmann, K. (2005). UVA1 and UVB irradiated skin investigated by optical coherence tomography in vivo: a preliminary study. Clin. Exp. Dermatol., 30(1): 79–82. https://doi.org/10.1111/j.1365-2230.2004.01690.x.

Kimura, T. & Doi, K. (1995). Dorsal Skin Reactions to Sunlight and Artificial Ultraviolet Light in Hairless Descendants of Mexican Hairless Dogs. Exp. Anim., 44(4): 293–299. https://doi.org/10.1538/expanim.44.293.

Kroemer, G., Galluzzi, L., Vandenabeele, P., Abrams, J., Alnemri, E.S., Baehrecke, E.H., Blagosklonny, M.V. et al. (2009). Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ., 16: 3–11. https://doi.org/10.1038/cdd.2008.150.

Lee, J.K., Kim, J.H., Nam, K.T. & Lee, S.H. (2003). Molecular events associated with apoptosis and proliferation induced by ultraviolet-B radiation in the skin of hairless mice. J. Dermatol. Sci., 32(3): 171–179. https://doi.org/10.1016/s0923-1811(03)00094-x.

Lowe, N.J., Meyers, D.P., Wieder, J.M., Luftman, D., Borget, T., Lehman, M.D., Johnson, A.W. & Scott, I.R. (1995). Low doses of repetitive ultraviolet A induce morphologic changes in human skin. J. Invest. Dermatol., 105(6): 739–743. https://doi.org/10.1111/1523-1747.ep12325517.

Lu, Y.-P., Lou, Y.-R., Yen, P., Mitchell, D., Huang, M.-T. & Conney, A.H. (1999). Time Course for Early Adaptive Responses to Ultraviolet B Light in the Epidermis of SKH-1 Mice. Cancer Res., 59(18): 4591–4602.

Murphy, G., Young, A.R., Wulf, H.C., Kulms, D. & Schwarz, T. (2001). The molecular determinants of sunburn cell formation. Exp. Dermatol., 10(3): 155–160. https://doi.org/10.1034/j.1600-0625.2001.010003155.x.

Naik, E., Michalak, E.M., Villunger, A., Adams, J.M. & Strasser, A. (2007). Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa. J. Cell Biol., 176(4): 415–424. https://doi.org/10.1083/jcb.200608070.

Ouhtit, A., Muller, H.K., Davis, D.W., Ullrich, S.E., McConkey, D. & Ananthaswamy, H.N. (2000). Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am. J. Pathol., 156(1): 201–207. https://doi.org/10.1016/S0002-9440(10)64720-7.

Papazoglou, E., Sunkari, C., Neidrauer, M., Klement, J.F. & Uitto, J. (2010). Noninvasive assessment of UV-induced skin damage: comparison of optical measurements to histology and MMP expression. Photochem. Photobiol., 86(1): 138–145. https://doi.org/10.1111/j.1751-1097.2009.00634.x.

Sano, T., Kume, T., Fujimura, T., Kawada, H., Moriwaki, S. & Takema, Y. (2005). The formation of wrinkles caused by transition of keratin intermediate filaments after repetitive UVB exposure. Arch. Dermatol. Res., 296(8): 359–365. https://doi.org/10.1007/s00403-004-0533-9.

Seité, S., Zucchi, H., Moyal, D., Tison, S., Compan, D., Christiaens, F., Gueniche, A. & Fourtanier, A. (2003). Alterations in human epidermal Langerhans cells by ultraviolet radiation: quantitative and morphological study. Br. J. Dermatol., 148(2): 291–299. https://doi.org/10.1046/j.1365-2133.2003.05112.x.

Svobodova, A., Walterova, D. & Vostalova, J. (2006). Ultraviolet light induced alteration to the skin. Biomed. Pap. Med. Fac. Univ. Palacky Olomouc Czech. Repub., 150(1): 25–38. https://doi.org/10.5507/bp.2006.003.

Takema, Y., Nishijima, A., Ohsu, H., Fujimura, T. & Hattori, M. (1997). Skin morphology at the time of UV irradiation is important for wrinkle formation. J. Soc. Cosmet. Chem., 48: 297-306.

Tronnier, M., Smolle, J. & Wolff, H.H. (1995). Ultraviolet irradiation induces acute changes in melanocytic nevi. J. Invest. Dermatol., 104(4): 475–478. https://doi.org/10.1111/1523-1747.ep12605910.

Viac, J., Goujon, C., Misery, L., Staniek, V., Faure, M., Schmitt, D. & Claudy, A. (1997). Effect of UVB 311 nm irradiation on normal human skin. Photodermatol. Photoimmunol. Photomed., 13(3): 103–108. https://doi.org/10.1111/j.1600-0781.1997.tb00125.x.

WMO (2003). Scientific Assessment of Ozone Depletion: 2002. Global Ozone Research and Monitoring Project-Report No. 47. World Meteorological Organization, Geneva, Switzerland.

Downloads

Published

01-07-2014

How to Cite

Saxena, P. N., Khanam, N. S., & Saxena, N. (2014). Anatomical Changes in the Skin of Rattus norvegicus after Artificial UV Exposure. Journal of Advanced Laboratory Research in Biology, 5(3), 71–78. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/190

Issue

Section

Articles