Toxicological Profile of Aluminium Sulphate and Effect on Protein Profile in Albino Rat
Keywords:Toxicological Profile, Protein Profile, Aluminium Sulphate, Albino Rat
World is full of xenobiotic substances such as heavy metal, pesticide and other pollutic agents. Heavy metal is a metallic element of relatively high density greater than 4gm/cm3 or 5 times more greater than water and is toxic even at low concentration. Heavy metals occur as a natural constituent of earth crust, can be emitted into environment by both natural and anthropogenic causes. Major cause of emission is the mining operations. Predetermined doses of aluminium sulphate in acute (1d) and subacute (7, 14, 21, 28ds) treatments revealed significant increase in albumin and globulin. The results are encouraging and highlight the toxic profile of aluminum sulphate and its effect on protein profile in albino rat.
. Connor, D.J., Jope, R.S., Harrell, L.E. (1988) Chronic, oral aluminum administration to rats: cognition and cholinergic parameters. Pharmacol. Biochem. Behav., 31(2):467-74.
. Duruibe, J.O., Ogwuegbu, M.O.C. and Egwurugwu, J.N. (2017). Heavy metal pollution and human biotoxic effect. Int. J. Phy. Sci., 2(5): 112-118.
. Finney, D.J. (1971). Probit Analysis. Cambridge University Press, 303 pp.
. Arora, S., Saxena, P.N. and Sharma, H.N. (2017). Serum biochemical alterations in albino rats following decis intoxication. International Journal of Interdisciplinary Research, 4(6): 7-12.
. Shaw, C.A., Seneff, S., Kette, S.D., Tomljenovic, L., Oller, J.W. Jr., Davidson, R.M. (2014). Aluminium-induced entropy in biological systems: implications for neurological disease. J. Toxicol., 2014:491316, pp 1-27, doi:10.1155/2014/491316.
. Singh, N.D., Sharma, A.K., Dwivedi, P., Patil, R.D., Kumar, M. and Basheer Ahamad, D. (2007). Toxicity of endosulfan and citrinin alone and in combination in pregnant rats: Clinico-haematological and serum biochemical alterations. Indian J. Vet. Pathol., 30(1): 27-31.
. Umminger, B.L. (1977). Relation of whole blood sugar concentrations in vertebrates to standard metabolic rate. Comparative Biochemistry and Physiology Part A: Physiology, 55: 457-460.