Toxicity Assessment of Nickel Nitrate and Effect on Total Leucocyte Count in Albino Rat
Keywords:Toxicity Assessment, LD50, Nickel Nitrate, TLC, Albino Rat
Heavy metals contribute a variety of adverse health effects. There are over 20 different heavy metal toxins that can impact health effects and each toxin produces different behavioural and physiological misconduct in an exposed individual. Heavy metals have bioimportance as trace element but the biotoxic effects of many of them in human biochemistry are of great concern. Hence, there is a need for understanding of the conditions such as concentration and oxidation states which make them harmful and how biotoxicity occurs. Nickel nitrate affects body physiology following its absorption through food, water and air. Predetermined doses of nickel nitrate (Ni(NO3)2] in acute (1d) and subacute (7, 14, 21, 28ds) treatments revealed significant increase in total leucocyte count (TLC). The results indicate extent of toxicity and enhancement in total leucocyte count under toxic stress of nickel nitrate in albino rat.
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