Effect of Carbamate Insecticide, Lannate, on the Gonads of Mice

  • A. M.T. Saleh Biology Department, Faculty of Applied Sciences, Umm Al-Qura University, Makka, 21955, PO Box 715, Kingdom of Saudi Arabia.
  • A. M. Hijji Biology Department, Faculty of Applied Sciences, Umm Al-Qura University, Makka, 21955, PO Box 715, Kingdom of Saudi Arabia.
  • S. J. Elel Biology Department, Faculty of Applied Sciences, Umm Al-Qura University, Makka, 21955, PO Box 715, Kingdom of Saudi Arabia.
  • A. N. Al Yacoub Biology Department, Faculty of Applied Sciences, Umm Al-Qura University, Makka, 21955, PO Box 715, Kingdom of Saudi Arabia.
Keywords: Testis, Ovary, Histological examination, Seminiferous tubules, Ovarian follicles, Corpora lutea

Abstract

The effect of the carbamate insecticide, lannate, on the gonads of mice was studied. Treating mice with lannate at a dose level of 10mg/kg body weight daily for 3-6 weeks had induced degenerative effects in the gonads, as follows, first in testis, a significant reduction in the diameter of the seminiferous tubules and germinal epithelial height. Histological examination of the testis showed that the seminiferous tubules were elongated and contained reduced spermatogenic cells. The number, of mature sperms was markedly reduced and after 3 weeks the sperm bundles were completely absent. On the other hand, the effect on the ovarian structure showed that, decrease in the number of secondary ovarian follicles and corpora lutea was recorded, while, the number of atretic follicles showed a significant increase. It is speculated that it may be resulted from the inhibition of RNA synthesis due to the effect of lannate.

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References

[1]. Aciole, E.H., Guimarães, N.N., Silva, A.S., Amorim, E.M., Nunomura, S.M., Garcia. A.C., Cunha, K.S. and Rohde, C. (2014). Genetic toxicity of dillapiol and spinosad larvicides in somatic cells of Drosophila melanogaster. Pest Manag Sci., 70(4):559-65.
[2]. Aldridge, W.N. and L. Magos (1978). “Carbamates, thiocarbamates, dithiocarbamates”, Luxembourg, Commission of the European Communities, Report No. V/F/1/78/75 EN.
[3]. Amarose, A.P. and Czajka, D.M. (1962). Cytopathic effects of deuterium oxide on the male gonads of the mouse and dog. Exp. Cell Res., 26: 43-61.
[4]. Amr, M.M., Halim, Z.S. and Moussa, S.S. (1997). Psychiatric disorders among Egyptian pesticide applicators and formulators. Environ. Res., 73(1-2):193-9.
[5]. Boseila, A., El-Refaei, A., Matter, F., Farid, F. and Saleh, N. (1981). A histological and quantitative study on ovaries of rats treated with an insecticide, carbaryl. Egypt. J. Histol., 4(2): 147 – 152.
[6]. Dikshith, T.S. and Datta, K.K. (1972a). Effect of intratesticular injection of lindane and endrin on the testes of rat. Acta Pharmacol. Toxiocol., 31: 1-10.
[7]. Dikshith, T.S. and Datta, K.K. (1972b). Pathologic changes induced by pesticides in the testes and liver of rats. Exp. Pathol. (Jena), 7: 309-316.
[8]. El-Samannody, F.A., Moussa, M.A., Abdel-Aal, M.E., Khater, M.O. and El-Assaby, M.A (1986). The effect of kepone injection on the testis of adult mice. Egypt. J. Histol., 9: 251 – 254.
[9]. El-Sayyad, H.I. (1994). Histological effects of thiosicarb on the reproductive system of the adult female mouse. J. Egypt. Germ. Soc. Zool., 13(C) 47-65.
[10]. Eroschenko, V.P. and Wilson, W.O. (1975). Cellular changes in the gonads, liver and adrenal glands of Japanese quail as affected by the insecticide, kepone. Toxicol. Appl. Pharmacol., 31: 491-504.
[11]. Espir, M.L., Hall, J.W., Shirreffs, J.G. and Stevens, D.L. (1970). Impotence in farm workers using toxic chemicals. Br. Med. J., 1: 423-5.
[12]. Fikes, J.D. (1990). Organophosphorus and carbamate insecticides. Vet. Clin. North Am.: Small Anim Pract., 20: 353-367.
[13]. Ganong, W.F. (1977). Review of Medical Physiology, Lange Medical Publications, Los Altos, California, PP. 330-337.
[14]. Habib, M.K., Hashem, S.M., Farid, N., Shawky, N. and Gad, S. (1981). Effect of diazinon insecticide on the ovarian structure of rat. Egypt. J. Histol. 4 (1): 29 – 35.
[15]. Heinrichs, W.L., Gellert, R.J., Bakke, J.L. and Lawrence, N.L. (1971). DDT administered to neonatal rats induces persistent estrus syndrome. Science, 173(3997):642-3.
[16]. Krause, W. and Homola, S. (1974). Alterations of the seminiferous epithelium and the Leydig cells of the mouse testis after the application of dichlorvos (DDVP). Bull. Environ. Contam. Toxicol., 11(5): 429-33.
[17]. Mahgoub, A.A., El-Medany, A.H. (2001). Evaluation of chronic exposure of the male rat reproductive system to the insecticide methomyl. Pharmacol. Res., 44(2):73-80.
[18]. Matsumura, F., Boush, G.M. and Misato, T. (1979). Environmental toxicology of pesticides. Academic Press, New York.
[19]. Matter, F.E., Farid, N.M. and Rageb, A.F. (2000). A histochemical study on the ovaries of rat treated with an insecticide. "Carbaryl". Egypt. J. Histol., 4(1): 87-92.
[20]. McEwen, F.L. and Stephenson, G.R. (1979). The use and significance of pesticides in the environment. John Wiley and Sons. New York.
[21]. Moussa, T.A. and Abdel-Hafez, M.M. (1982). Effect of dimethoate on the guinea pig testis. Egypt. J. Histol., 5: 181-189.
[22]. Newton, D.W. and Hayes, R.I. (1968). Histological studies of ovaries in rats treated with hydroxybiphenyl tin acetate and triphenyltin chloride. J. Econ. Entomol. 61: 1668 – 1669.
[23]. Peters, H., Byskov, A.G., Himelstein-Braw, R., Faber, M. (1975). Follicular growth: The basic event in the mouse and human ovary. J. Reprod. Fertil., 45: 559 – 566.
[24]. Polsky, J.Y., Aronson, K.J., Heaton, J.P., Adams, M.A. (2007). Pesticides and polychlorinated biphenyls as potential risk factors for erectile dysfunction. J. Androl., 28(1):28-37.
[25]. Sakr, S.A., El-Saadany, M.M. and Abdel-Galil, A.M. (1988). A histological study on the ovaries of hamsters fed with an insecticide, dimethoate. J. Med. Res. Instit., 9(3): 57-65.
[26]. Sakr, S.A. and Salib, E.A. (1987). Effect of dimethoate on spermatogenesis in hamster Mesocricetus auratus. Alex. J. Agric. Res., 32: 491-499.
[27]. Shalaby, M.A., El Zorba, H.Y. and Ziada, R.M. (2010). Reproductive toxicity of methomyl insecticide in male rats and protective effect of folic acid. Food Chem. Toxicol., 48(11):3221-6.
[28]. Shanthalatha, A., Madhuranath, B.N., Yajurvedi, H.N. (2012). Effect of methomyl formulation, a carbamate pesticide on ovarian follicular development and fertility in albino mice. J. Environ. Biol., 33(1):33-7.
[29]. Shtenberg, A.I. and Ozhovan, M.V. (1971). The Effect of low sevin doses on the reproductive function of animals in a number of generations. Vopr. Pitan., 30: 42.
[30]. Shtenberg, A.I., Orlova, N.V. and Torchinskii, A.M. (1973). Actions of pesticides of different chemical structures on the gonads and embryogenesis of experimental animals. Gig. Sanit., 38: 16-20.
[31]. Smith, M.T., Thomas, J.A., Smith, C.G., Mawhinney, M.G., Lloyd, J.W. (1972). Effects of DDT on radioactive uptake from testosterone-1,2- 3 H by mouse prostate glands. Toxicol. Appl. Pharmacol., 23(1): 159-164.
[32]. Swartz, W.J. and Mall, G.M. (1989). Chlordecone-induced follicular toxicity in mouse ovaries. Reprod. Toxicol., 3: 203 – 206.
[33]. Zuckerman, L. and Weir, B.J. (1977). The ovary: general aspects. Academic Press, INC, New York, London, PP. 266 – 284.
Published
2014-10-01
How to Cite
Saleh, A., Hijji, A., Elel, S., & Al Yacoub, A. (2014). Effect of Carbamate Insecticide, Lannate, on the Gonads of Mice. Journal of Advanced Laboratory Research in Biology, 5(4), 140-145. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/208
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Articles