Histopathological Effects on the Eye Development during Perinatal Growth of Albino Rats Maternally Treated with Experimental Phenylketonuria during Pregnancy

  • Mahmoud E. Mohallal Zoology Department, Faculty of Science, Suez Canal University, Egypt.
  • Hany A. Hefty Zoology Department, Faculty of Science, Suez Canal University, Egypt.
  • Hassan I. Elsayyad Zoology Department, Faculty of Science, EL Mansoura University, Egypt.
  • Hala M. Ebied Zoology Department, Faculty of Science, Suez Canal University, Egypt.
Keywords: PKU, Eye, Perinatal, Rat

Abstract

Phenylketonuria (PKU) is a genetic disorder that is characterized by an inability of the body to utilize the essential amino acid, phenylalanine. The disease results from a deficiency in phenylalanine hydroxylase, the enzyme catalyzing the conversion of phenylalanine to tyrosine. Although, this inborn error of metabolism was among the first in humans to be understood biochemically and genetically, little is known about the mechanisms involved in the pathology of PKU during neonatal brain development. Elevated concentrations of plasma phenylalanine were induced in pregnant rats by oral administration of 50mg/100g body weight alpha-methylphenylalanine plus phenylalanine supplementation at a dosage of 60mg/100g body weight two times daily after 6th day of onset of gestation till 14 & 16 days prenatal as well as at parturition. Treatment with alpha-methylphenylalanine resulted in significant reduction of retinal cell layers of prenatal fetuses and delivered newborns.   Histological abnormalities were detected manifested by either hyaline degeneration of lens structure or inducing lens cataract as well as comparative atrophy of retina associated with the development of malignant polypoid mass in the ganglionic cell layers in contact with the lens.

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References

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Published
2016-04-01
How to Cite
Mohallal, M., Hefty, H., Elsayyad, H., & Ebied, H. (2016). Histopathological Effects on the Eye Development during Perinatal Growth of Albino Rats Maternally Treated with Experimental Phenylketonuria during Pregnancy. Journal of Advanced Laboratory Research in Biology, 7(2), 36-42. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/247
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Articles