Cuticular Biochemistry: Lambda-Cyhalothrin Induced Alterations in Mutant Drosophila melanogaster

  • Harendra N. Sharma Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002 (U.P.), India.
  • Prabhu N. Saxena Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002 (U.P.), India.
  • Vishnu Kumar Upadhyay Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002 (U.P.), India.
  • Namrata Rana Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002 (U.P.), India.
  • Nishi Saxena Toxicology Laboratory, Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B.R. Ambedkar University, Agra-282002 (U.P.), India.
Keywords: Insect, Cuticle, Pyrethroid

Abstract

Derivatives of natural pyrethrum, synthetic pyrethroids, are well-established neurotoxins. However, they do interfere with the functioning of metabolic processes; the most important of these is chitin metabolism, a key process in the development of insects. Type II synthetic pyrethroid, lambda-cyhalothrin, when orally fed to Drosophila melanogaster revealed its efficacy in chitin synthesis modulation. Total proteins, glucosamine, N-acetylglucosamine, chitinase activity and chitin content exhibit significant changes in the final developmental stage, the adults. A reduction in chitin synthesis is suggestive of interference in polymerization process which is a must for cuticle formation. Involvement of lambda-cyhalothrin in chitin synthesis has been sought to be an additional mode of action, other than its neurotoxic nature.

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Published
2016-07-01
How to Cite
Sharma, H., Saxena, P., Upadhyay, V., Rana, N., & Saxena, N. (2016). Cuticular Biochemistry: Lambda-Cyhalothrin Induced Alterations in Mutant Drosophila melanogaster. Journal of Advanced Laboratory Research in Biology, 7(3), 76-78. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/254
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Articles
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