Effects of Antidepressant Drug on Sexual Behavior and Fitness Parameters of Drosophila ananassae

Authors

  • Bhasvarajapur Rajegowda Guruprasad Kannada Bharathi College, Kushalnagar, Madikeri, Karnataka 571234, India.
  • Sridhar Narayana Hegde Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore-571602, India.

Keywords:

Fecundity, Mating, Fertility, Hatchability, Viability

Abstract

Drosophila is a suitable model organism in the field of toxicological science. The objective of this study was to explore the potential of doxepin, an antidepressant drug, on sexual behavior and fitness of Drosophila ananassae. Sexual behavior such as mating latency and copulation duration was higher as concentration of antidepressant increases in both larval and adult feeding methods, decrease in the fecundity and fertility was also observed in adult feeding than larval feeding methods. According to the Chi-Square, the percentage of the hatchability is decreased in treated compared with one control and significant difference in viability in adult feeding method. Our findings show the adult one which are exposed are more sensitive comparatively with larval stage. It was also noticed that antidepressant effects some behavioral aspects of Drosophila.

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References

Andrewartha, H.G. & Birch, L.C. (1954). The distribution and abundance of animals. University of Chicago Press, Chicago, pp. 782.

Baldwin, D.S. (2001). Depression and sexual dysfunction. Br. Med. Bull., 57: 81–99. https://doi.org/10.1093/bmb/57.1.81.

Cassidy, S. & Henry, J. (1987). Fatal toxicity of antidepressant drugs in overdose. Br. Med. J. (Clin. Res. Ed.), 295: 1021–1024. https://doi.org/10.1136/bmj.295.6605.1021.

Delcour, J. (1969). A rapid and efficient method of egg-collecting. Drosophila Information Service, 44: 133-134.

Ewing, A.W. (1983). Functional Aspects of Drosophila Courtship. Biol. Rev., 58(2): 275–292. https://doi.org/10.1111/j.1469-185X.1983.tb00390.x.

Gruwez, G., Hoste, C., Lints, C.V. & Lints, F.A. (1971). Oviposition rhythm in Drosophila melanogaster and its alteration by a change in the photoperiodicity. Experientia, 27(12): 1414–1416. https://doi.org/10.1007/BF02154262.

Guruprasad, B.R. & Hegde, S.N. (2009). Sexual behavioral plasticity of D. melanogaster of Chamundi hill. Drosophila Information Service, 92: 5-6.

Guruprasad, B.R., Hegde, S.N. & Krishna, M.S. (2008). Positive Relation between Male Size and Remating Success in Some Populations of Drosophila bipectinata. Zoological Studies, 47(1): 75-83.

Parker, G. & Hadzi-Pavlovic, D. (Eds.) (1996). Melancholia: A Disorder of Movement and Mood: A Phenomenological and Neurobiological Review. Cambridge: Cambridge University Press. https://doi.org/10.1017/CBO9780511759024.

Hegde, S.N. & Krishna, M.S. (1997). Size-assortative mating in Drosophila malerkotliana. Anim. Behav., 54(2): 419–426. https://doi.org/10.1006/anbe.1996.0485.

Hegde, S.N. & Krishnamurthy, N.B. (1979). Studies on mating behaviour in the Drosophila bipectinata complex. Aust. J. Zool., 27(3): 421–431. https://doi.org/10.1071/ZO9790421.

Hegde, S.N., Vasudev, V. & Krishna, M.S. (2001). Biodiversity of Drosophila of South India. In: Hosetti, B.B. & Venkateshwarlu, M. (Eds.), Trends in wild life Biodiversity conservation and management, Daya Publishing House, New Delhi, pp. 55-73.

Henry, J.A. (1992). Toxicity of antidepressants: comparisons with fluoxetine. Int. Clin. Psychopharmacol., 6: 22–27.

Lüning, K.G. (1966). Drosophila-tests in Pharmacology. Nature, 209: 84–86. https://doi.org/10.1038/209084a0.

Nagabhushana (2002). Studies on the biodiversity of drosophilids in Devarayanadurga Karnataka India. Ph.D. thesis, Kuvempu University, Karnataka, India.

Nazir, A., Mukhopadhyay, I., Saxena, D.K., Siddiqui, M.S. & Chowdhuri, D.K. (2003). Evaluation of toxic potential of captan: Induction of hsp70 and tissue damage in transgenic drosophila melanogaster (hsp70-lacZ) Bg9. J. Biochem. Mol. Toxicol., 17(2): 98–107. https://doi.org/10.1002/jbt.10066.

Rao, K.P. & Rao, M.S. (1980). Mutagenic effects of fluphenazine hydrochloride in Drosophila melanogaster. Toxicol. Lett., 7(2): 161–164. https://doi.org/10.1016/0378-4274(80)90050-8.

Razdan, T., Rana, K.S. & Saxena, P.N. (2003). Effect of cybil on reproductive success of wild Drosophila melanogaster. J. Environ. Biol., 24(3): 345–347.

Basheer, S., Vasudev, V., Venu, R., Guruprasad, K.P. & Harish, S.K. (1999). Toxic effects of a recently introduced carbamate pesticide, Dunet (methomyl) on Drosophila melanogaster. J. Environ. Biol., 20(2): 135–139.

Spiess, E.B. (1970). Mating Propensity and Its Genetic Basis in Drosophila. In: Hecht, M.K. & Steere W.C. (eds), Essays in Evolution and Genetics in Honor of Theodosius Dobzhansky. Appleton-Century Crofts, New York, pp. 315–379. https://doi.org/10.1007/978-1-4615-9585-4_12.

Spieth, H.T. (1978). Courtship patterns and evolution of the Drosophila adiastola and Planitibia species subgroups. Evolution, 32(2): 435–451. https://doi.org/10.1111/j.1558-5646.1978.tb00658.x.

Spieth, H.T. (1966). Mating behavior of D. ananassae and ananassae-like flies from the Pacific. Univ. Tex. Publ., 6615: 133-145.

Spieth, H.T. (1968). Evolutionary Implications of Sexual Behavior in Drosophila. In: Dobzhansky, T., Hecht, M.K. & Steere, W.C. (eds), Evolutionary Biology. Plenum Press, New York, pp. 157-193. https://doi.org/10.1007/978-1-4684-8094-8_4.

Spieth, H.T. & Ringo, J.M. (1983). Mating behavior and sexual isolation in Drosophila. In: Ashburner, M., Carson, H.L. & Thompson, J.N., Jr (eds), The Genetics and Biology of Drosophila, Vol. 3c, Academic Press, London, pp. 223–284.

Strümper, D., Durieux, M.E., Tröster, B., Hahnenkamp, K., Vitan, C., den Bakker, C.G. & Hollmann, M.W. (2003). Effects of antidepressants on G protein-coupled receptor signaling and viability in Xenopus laevis oocytes. Anesthesiology, 99(4): 911–917. https://doi.org/10.1097/00000542-200310000-00025.

Tomaru, M., Matsubayashi, H. & Oguma, Y. (1998). Effects of Courtship Song in Interspecific Crosses among the Species of the Drosophila auraria Complex (Diptera: Drosophilidae). J. Insect Behav., 11(3): 383–398. https://doi.org/10.1023/A:1020954731063.

van Schaik, N. & Graf, U. (1991). Genotoxicity evaluation of five tricyclic antidepressants in the wing somatic mutation and recombination test in Drosophila melanogaster. Mutat. Res., 260(1): 99–104. https://doi.org/10.1016/0165-1218(91)90085-z.

Vasudev, V. & Krishnamurthy, N.B. (1982). Effect of Dithane M-45 on the rate of development, viability, morphology and fecundity in Drosophila melanogaster. J. Mysore Univ., 29: 79–86.

Vogel, E. (1972). Differential sensitivity of immature and mature oocytes of Drosophila melanogaster to the induction of dominant lethals following treatment by mono- and polyfunctional aziridine analogues. Mutat. Res., 14(2): 250–253. https://doi.org/10.1016/0027-5107(72)90052-8.

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Published

01-10-2010

How to Cite

Guruprasad, B. R., & Hegde, S. N. (2010). Effects of Antidepressant Drug on Sexual Behavior and Fitness Parameters of Drosophila ananassae. Journal of Advanced Laboratory Research in Biology, 1(2), 92–97. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/39

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