Histopathological Study of Subacute Toxic Effects of Chloroacetic Acid on Albino Rats and its Correlation with Serum Levels of Malondialdehyde
Human beings are increasingly being exposed to chloroacetic acid (CAA), a type of halo acetic acid. It would not be an exaggeration to say that almost the whole humankind today is affected by it or its metabolites. The concern over the carcinogenicity of haloacetic acids led the United States Environmental Protection Agency to regulate the allowable concentration of haloacetic acids in drinking water as part of the Disinfectants and Disinfection Byproducts Rule promulgated in 1998. Keeping this view in mind, the present study on histolopathological evaluation of different types of tissues viz., brain, kidney, liver, spleen and testes of Rattus norvegicus was performed, to find out the subacute toxicity of chloroacetic acid and correlation between CAA administration and changes in malondialdehyde (MDA) level in blood.
. Berg, M., Müller, S.R., Mühlemann, J., Wiedmer, A., Schwarzenbach, R.P. (2000). Concentrations and mass fluxes of chloroacetic acids and trifluoroacetic acid in rain and natural waters in Switzerland. Environ. Sci. Technol., 34: 2675–2683.
. Frank, H., Scholl, H., Renschen, D., Rether, B., Laouedj, A., Norokorpi, Y. (1994). Haloacetic acids, phytotoxic secondary air pollutants. Environ. Sci. Pollut. Res. Int., 1: 4–14.
. Urbansky, E.T. (2001). The fate of the haloacetates in drinking water-chemical kinetics in aqueous solution. Chem. Rev., 101: 3233–3243.
. Zeldenrust, J. (1951). A case of peracute poisoning by monochloroacetic acid. Arch. Belg. Med. Soc., 9:19–22.
. Pereira, M.A. (1996). Carcinogenic activity of dichloroacetic acid and trichloroacetic acid in the liver of female B6C3F1 mice. Fundam. Appl. Toxicol., 31: 192-199.
. Dote, T., Tominaga, M., Usuda, K. (2003). Acute toxicity of Chloroacetic acid exposure in rats. Bulletin of the Osaka Medical College, 49: 11-16.
. Toshina, Y., Dote, T., Usuda, K., Shimizu, H., Tominaga, M., Kono, K. (2004). Hepatic injury and gluconeogenesis after subcutaneous injection of monochloroacetic acid in rats. Environ. Health Prev. Med., 9(2):58-62.
. Demir, H., Celik, I. (2006). Acute effects of Trichloroacetic acid on serum enzyme levels and erythrocytes carbonic anhydrase activity in rats. Turk. J. Biol., 30: 121-125.
. Kulling, P., Andersson, H., Boström, K., Johansson, L.A., Lindström, B., Nyström, B. (1992). Fatal systemic poisoning after skin exposure to monochloroacetic acid. J. Toxicol. Clin. Toxicol., 30(4):643-652.
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