Total Serum Cholesterol Level in Cases of Carcinoma Breast – A Correlative Study

  • Kafil Akhtar Department of Pathology, Jawaharlal Nehru Medical College, Aligarh-202001, India.
  • S. Shamshad Ahmad Department of Pathology, Jawaharlal Nehru Medical College, A.M.U., Aligarh-202001, India.
  • Sabina Ashraf Emergency, Jawaharlal Nehru Medical College, A.M.U., Aligarh-202001, India.
  • Arshad Jamal Departments of Surgery, Jawaharlal Nehru Medical College, A.M.U., Aligarh-India.
Keywords: Breast Cancer, Serum Cholesterol, Prognosis

Abstract

Aims and Objective: Correlation between serum cholesterol level and risk of breast cancer.

Material and Methods: Fifty histologically diagnosed breast cancer patients were included in the study. Patients were grouped according to the size, histological type of the tumor and lymph node involvement. Patient’s total serum cholesterol levels were measured a week prior to the operation and on the 14th day postoperatively. Fifty age-matched non-cancer females were treated as a control.

Observations: The pre and postoperative mean total serum cholesterol (MTSC) was found to be 272.3 ± 43.4mg/dl and 210.54 ± 31.5mg/dl respectively. An MTSC level in fifty control cases was found to be 183.42 ± 34.4mg/dl. Patients with tumor size less than 5cms showed preoperative mean serum cholesterol levels of 261.6 ± 36.5mg/dl and a postoperative value of 201.9 ± 16.9mg/dl while those with tumor size more than 10cms showed a mean serum cholesterol level of 282.36 ± 64.8mg/dl preoperatively and 211.82 ± 53.15mg/dl postoperatively. Thirty patients with scirrhous type of carcinoma had a preoperative mean serum cholesterol level as 237.36mg/dL, and twelve patients with a colloid type of carcinoma showed a preoperative level of 294.9 ± 18.4mg/dL whereas eight patients with medullary type of carcinoma showed the highest preoperative level of 324.3 ± 19.8mg/dL, whereas the corresponding postoperative values were 202.9 ± 30.0mg, 216.8 ± 27.8mg and 229.4 ± 29.8mg respectively.

Conclusions: The present study helps us to conclude that dietary habits affect the association of cholesterol in breast cancer and size, histology with tumor metastasis effects such relationship.

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References

[1]. Chao, F.C., Efron, B., Wolf, P. (1975). The possible prognostic usefulness of assessing serum proteins and cholesterol in malignancy. Cancer, 35: 1223-1229.
[2]. Rose, G., Shipley, M.J. (1980). Plasma lipids and mortality: A source of error. Lancet, 1: 523-526.
[3]. Alexopoulos, C.G., Blatsios, B., Avgerinos, A. (1987). Serum lipids and lipoprotein disorders in cancer patients. Cancer, 60: 3065-3070.
[4]. Allain, C.C., Poon, L.S., Chan, C.S., Richmond, W., Fu, P.C. (1974). Enzymatic determination of total serum cholesterol. Clin. Chem., 20: 470-475.
[5]. Alexopoulos, C.G., Pournaras, S., Vaslamatzis, M., Avgerinos, A., Raptis, S. (1992). Changes in serum lipids and lipoproteins in cancer patients during chemotherapy. Cancer Chemother. Pharmacol., 30: 412-416.
[6]. Knekt, P., Reunanen, A., Aromaa, A., Heliövaara, M., Hakulinen, T., Hakama, M. (1988). Serum cholesterol and risk of cancers in a cohort of 39,000 men and women. J. Clin. Epidemiol., 41: 519-530.
[7]. Smith, C.D., Shipley, M.J., Marmot, M.G., Rose G. (1992). Plasma Cholesterol concentration and mortality: The Whitehall study. JAMA, 267: 70-76.
[8]. Miller, A.B., Kelly, A., Choi, N.W., Matthews, V., Morgan, R.W., Munan, L., Burch, J.D., Feather, J., Howe, G.R., Jain, M. (1978). A study of diet and breast cancer. Am. J. Epidemiol., 107: 499-509.
[9]. Hiatt, R.A. and Fireman, B.H. (1986). Serum cholesterol and the incidence of cancer in a large cohort. J. Chronic. Dis., 39: 861-870.
[10]. Schatzkin, A., Hoover, R.N., Taylor, P.R., Ziegler, R.G., Carter, C.L., Albanes, D., Larson, D.B., Licitra, L.M. (1988). Site-specific analysis of total serum cholesterol and incident cancer in the National Health and Nutrition Examination Survey I Epidemiological Follow-up Study. Cancer Research, 48: 452-458.
Published
2012-04-01
How to Cite
Akhtar, K., Ahmad, S., Ashraf, S., & Jamal, A. (2012). Total Serum Cholesterol Level in Cases of Carcinoma Breast – A Correlative Study. Journal of Advanced Laboratory Research in Biology, 3(2), 58-61. Retrieved from https://e-journal.sospublication.co.in/index.php/jalrb/article/view/99
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Articles